Founders who took it from hypothesis to patent-pending.

Thea Biosciences is a focused founding team. We architected the platform, ran the campaigns, produced the cross-validated lead series, and filed the IP — end to end. We're now assembling the scientific bench to take it into the lab.

Jananthan ParamsothyJPMD · MPH

Jananthan Paramsothy, MD, MPH

Founder · Pipeline Architect

Jananthan is a physician-scientist — MD, and an Executive MPH in Health Informatics from the Yale School of Public Health — with 10+ years across Phase I–III clinical trials, inpatient medicine, pharmacovigilance, and health informatics. He architected and built Thea Biosciences' end-to-end computational discovery pipeline (pocket-aware generation, physics-based screening, multi-parameter safety optimization), led the ApoE4 campaign that produced the cross-validated lead series, and drove the provisional patent filing — pairing clinical and regulatory rigor (FDA / ICH / GCP) with data-driven drug discovery.

Contact email
partnerships@theabiosciences.com

Ramja SritharanRSPhD(c) · Mount Sinai

Ramja Sritharan, PhD(c)

Co-Founder · Scientific Strategy

Ramja is a cancer scientist at the Icahn School of Medicine at Mount Sinai studying how tumors evade immune attack and how to overcome resistance to immunotherapy. Her peer-reviewed work — in Nature Communications, Cell Reports, JCI Insight, and CMGH — spans immuno-oncology and functional cancer genomics, connecting disease mechanism to therapeutic opportunity. At Thea Biosciences she defines the biological and translational framework behind each program: grounding platform-generated candidates in real disease biology, designing the validation strategy from prediction to proof, and leading the scientific diligence and partnerships that move them toward the clinic.

Contact email
partnerships@theabiosciences.com

How we work

Small team. High bar. Real results.

/ 01

Evidence over assertion

We claim only what we can show. "Computational" is stated plainly; the wet lab is the next bar, not a footnote.

/ 02

Hard targets, on purpose

We chose the strongest genetic driver of Alzheimer's precisely because it's hard. That's where a real platform proves itself.

/ 03

Protect the edge

We share results openly and guard methods rigorously. The recipe is the company.

Building the bench

We're assembling our scientific circle.

A small founding team took Titan from hypothesis to a patent-pending, cross-validated lead series. To take it into the lab, we're adding advisors and partners across the capabilities a preclinical program needs — these seats are open now.

Advisory — open

Medicinal chemistry

Synthetic route & lead optimization toward an IND-enabling candidate.

Advisory — open

ApoE / neurodegeneration biology

Cellular assay design and ApoE structure-correction translation.

Partner — open

Assay development / CRO

SPR / ITC, cellular correction assays, and in-vitro ADME/PK.

Advisory — open

IP & patent counsel

Composition-of-matter prosecution and freedom-to-operate.

Advisory — open

Pharma BD / scientific diligence

Partnering strategy and diligence readiness for CNS / ApoE programs.

Let's build the future of ApoE4 therapeutics.

Whether you're a partner, advisor, or investor — we'd like to hear from you.

Or email us directly — partnerships@theabiosciences.com